ログイン 会員登録
icon_bulk_order一括注文 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
phone
Your Position: ホーム > CD79A & CD79B

CD79A & CD79B

概要

Name:B-cell antigen receptor complex-associated protein beta chain
Target Synonym:B-Cell Antigen Receptor Complex-Associated Protein Beta Chain,B29,Immunoglobulin-associated B29 protein,Ig-beta,B-cell-specific glycoprotein B29,CD79B,CD79b Molecule,CD79b Molecule, Immunoglobulin-Associated Beta,IGB,CD79B Antigen (Immunoglobulin-Associated Beta),CD79b Antigen,AGM6
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

製品リスト製品比較と製品注文

ACRO Quality

生物活性データの一部

SCCHO-ATP170-Cell-based assay
 CD79A & CD79B FACS

Expression analysis of human CD79A on CHO/Human CD79A&CD79B Stable Cell Line by FACS.
Intracellular staining was performed on CHO/Human CD79A&CD79B Stable Cell Line or negative control cell using FITC-labeled anti-human CD79A antibody after fixation and permeabilization.

SCCHO-ATP170-Cell-based assay
 CD79A & CD79B FACS

Expression analysis of human CD79B on CHO/Human CD79A&CD79B Stable Cell Line by FACS.
Cell surface staining was performed on CHO/Human CD79A&CD79B Stable Cell Line or negative control cell using APC-labeled anti-human CD79B antibody.

CDB-H52W3-MALS-HPLC
CD79A & CD79B MALS images

The purity of Human CD79A&CD79B Heterodimer Protein, Mouse IgG2a Fc,Flag Tag&Mouse IgG2a Fc,His Tag (Cat. No. CDB-H52W3) is more than 85% and the molecular weight of this protein is around 110-150 kDa verified by SEC-MALS.

CDB-H52W3-ELISA
 CD79A & CD79B ELISA

Immobilized Human CD79A&CD79B Heterodimer Protein, Mouse IgG2a Fc,Flag Tag&Mouse IgG2a Fc,His Tag (Cat. No. CDB-H52W3) at 1 μg/mL (100 μL/well) can bind Polatuzumab with a linear range of 0.1-1 ng/mL (QC tested).

CD79A & CD79B Molecule Synonym Name

CD79A&CD79B, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain

CD79A & CD79B Molecule Background

CD79a and CD79b heterodimers are the important signaling components of B cell receptor (BCR) complex which plays a crucial role in B cell development and antibody production. BCR complexes are composed of a ligand-binding receptor (membrane immunoglobulin; mIg), non-covalently associated with the signaling com-ponent, a disulfide-linked heterodimer of CD79a (Igα) and CD79b (Igβ). Both CD79 subunits consist of an Ig-like domain, a transmembrane (TM) region, and a longer cytoplasmic tail (CYT) containing an immune-receptor tyrosine-based activation motif (ITAM).

CD79A & CD79B References

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Polatuzumab vedotin RO-5541077-000; FCU-2711; DCDS-4501A; RG-7596; RO-5541077 Approved Genentech Inc Polivy United States Lymphoma, Large B-Cell, Diffuse Genentech Inc 2019-06-10 Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell Details
Polatuzumab vedotin RO-5541077-000; FCU-2711; DCDS-4501A; RG-7596; RO-5541077 Approved Genentech Inc Polivy United States Lymphoma, Large B-Cell, Diffuse Genentech Inc 2019-06-10 Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
PRV-3279 HDM-3002; MGD-010; PRV-3279; CD32BxCD79B Phase 2 Clinical Macrogenics Inc Lupus Erythematosus, Systemic Details
CD19/79b Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR CD19/79b Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Lymphoma, B-Cell; Leukemia, B-Cell Details
TolDCB29 Phase 2 Clinical Umc Utrecht Arthritis, Rheumatoid Details
SHR-A1912 SHR-A1912 Phase 2 Clinical Shanghai Hengrui Pharmaceutical Co Ltd Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Lymphoma Details
CD79b-19 CAR T Cells Therapy (Massachusetts General Hospital) Phase 1 Clinical Massachusetts General Hospital Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin Details
Autologous CD79b-targeting Chimeric Antigen Receptor T-cell Therapy(MD Anderson Cancer Center) JV-213 Phase 1 Clinical The University Of Texas MD Anderson Cancer Center Lymphoma, B-Cell; Lymphoma Details
NBT-508 Phase 1 Clinical Newbio Therapeutics Inc Lymphoma, B-Cell; Lymphoma, Non-Hodgkin Details
CD79b CAR-T cell therapy (Yake Biotechnology) Phase 1 Clinical Zhejiang University Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Biphenotypic, Acute Details
Iladatuzumab vedotin DCDS-0780A; RO-7032005 Phase 1 Clinical F. Hoffmann-La Roche Ltd Lymphoma, Non-Hodgkin Details
PRV-3279 HDM-3002; MGD-010; PRV-3279; CD32BxCD79B Phase 2 Clinical Macrogenics Inc Lupus Erythematosus, Systemic Details
CD19/79b Bi-specific CAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) bi-4SCAR CD19/79b Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Lymphoma, B-Cell; Leukemia, B-Cell Details
TolDCB29 Phase 2 Clinical Umc Utrecht Arthritis, Rheumatoid Details
SHR-A1912 SHR-A1912 Phase 2 Clinical Shanghai Hengrui Pharmaceutical Co Ltd Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Lymphoma Details
CD79b-19 CAR T Cells Therapy (Massachusetts General Hospital) Phase 1 Clinical Massachusetts General Hospital Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin Details
Autologous CD79b-targeting Chimeric Antigen Receptor T-cell Therapy(MD Anderson Cancer Center) JV-213 Phase 1 Clinical The University Of Texas MD Anderson Cancer Center Lymphoma, B-Cell; Lymphoma Details
NBT-508 Phase 1 Clinical Newbio Therapeutics Inc Lymphoma, B-Cell; Lymphoma, Non-Hodgkin Details
CD79b CAR-T cell therapy (Yake Biotechnology) Phase 1 Clinical Zhejiang University Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Biphenotypic, Acute Details
Iladatuzumab vedotin DCDS-0780A; RO-7032005 Phase 1 Clinical F. Hoffmann-La Roche Ltd Lymphoma, Non-Hodgkin Details

This web search service is supported by Google Inc.

totopphone